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The potential role of agrmediated quorum sensing is not as clear in other host environments. We and other researchers have shown through in vivo human and animal studies that agr appears to be unnecessary in certain infections for the expression of secreted virulence factors For example agr expression in a rabbit abscess model was decreased at the same time that the animals developed TSS through exotoxin production In addition an agr mutant was just as effective at causing TSS as the isogenic wildtype organism.

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