Dear colleagues,
don't forget today's seminar at 12.15 via zoom (link below).
The speaker is Dr. Lotta-Riina Sundberg from University of Jyväskylä, on
"Is the test tube telling the whole story? Impact of the mucosal environment on phage-bacterium interplay"
Mucosal surfaces are the first barriers against invading pathogens. However, in addition to immune functions, the outmost layers of mucosal surfaces maintain tissue-specific microbiomes. Viruses, such as bacteriophages are major partners in the microbiomes of the mucosal milieu, contributing to the dynamics of their bacterial hosts. Indeed, many phages have Ig-like binding domains in their structural proteins the capacity to bind to mucins, the large glycoproteins giving the viscous properties for the mucosal surface. This has led to the Bacteriophage Adherence to Mucus -(BAM) hypothesis: eukaryotes accommodate phages on their mucosal surfaces to provide external immunity against bacterial disease. This may have resulted into a symbiotic relationship between metazoans and phages, in which the metazoan host provides phages an environment to encounter bacterial hosts, and phages protect from bacterial infections in this process. We have studied phage binding on mucus and the effect of mucosal environment on phage-bacterium interactions. Our results show that phage adhesion to mucus results in preventive protection against bacterial infections. Interestingly, exposure to mucus upregulates bacterial virulence, which is exploited by phages for infection by increasing infection rate. In response, mucosal environment change the ecology of bacterial resistance against phages by increasing the activity of the CRISPR-Cas adaptation. These results suggest that the traditional co-culture studies may give a biased view on host-associated phage-bacterium interactions, which is strongly influenced by the chemical cues of the metazoan host. This phenomenon might be widespread in the biosphere and thus crucial for understanding mucosal diseases, their outcome and treatment.
Lotta-Riina is an associate professor at the Department of Biological and environmental science, and the Nanoscience Center in Jyväskylä, find out more on her research here:
https://lrsundberg.weebly.com/
The rest of the seminar program for the spring is under construction, but we have a few speakers confirmed already:
https://thursdayseminarbiology.wordpress.com/
See you soon,
Heikki
Heikki Helanterä is inviting you to a scheduled Zoom meeting.
Topic: Biology Thursday seminar
Time: This is a recurring meeting Meet anytime
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Heikki Helanterä
Associate Professor (tenure track)
Ekologian ja genetiikan tutkimusyksikkö / Ecology and Genetics Research Unit
Oulun Yliopisto / University of Oulu / Finland
heikki.helantera(a)oulu.fi<mailto:heikki.helantera@oulu.fi>
+358-40-7507 334
Hello everybody,
We will have the FlashSmart CHNS/O installed in B157 next weeks wednesday 20.1. and Mats Perätalo from Lab-Dig will be here 21-22.1. (Thursday and Friday) to teach us how to operate the machine.
Anybody who would be interested in the operation of the machine or have questions for Mats are welcome to join us on these dates!
BR,
Petri Sundqvist
Hanki Outlook for Android<https://aka.ms/ghei36>
Hei,
Tervetuloa kuuntelemaan FT Sami Kivelän opetusnäyte "Ikääntymisen (seneskenssin) evoluutio" eläinekologian dosentuuria varten 21.1. klo 14.15 Zoomissa: https://oulu.zoom.us/j/68365797453. Esitys kestää 20-30 minuuttia.
Terveisin,
Lumi
Maisteriseminaari 20.1.
Zoom: https://oulu.zoom.us/j/61550086160?pwd=bFJuMzJCZkFVTEdHSTF3ZHoxSjhmdz09
Klo 14:15 Matias Wolff: Pohjois-Suomen lehtojen muutos viimeisen 40v aikana indikaattori lajien kannalta (suunnitelma)
Opponentti. Susanna Mertanen
Ohjaajat: Lauralotta Muurinen, Risto Virtanen ja Tuija Maliniemi
Vastuuprofessori: Anna Liisa Ruotsalainen
Dear colleagues,
the first Biology Thursday seminar for 2021 is taking place on 21st Jan, at 12.15 via zoom (link below).
The speaker is Dr. Lotta-Riina Sundberg from University of Jyväskylä, on
"Is the test tube telling the whole story? Impact of the mucosal environment on phage-bacterium interplay"
Mucosal surfaces are the first barriers against invading pathogens. However, in addition to immune functions, the outmost layers of mucosal surfaces maintain tissue-specific microbiomes. Viruses, such as bacteriophages are major partners in the microbiomes of the mucosal milieu, contributing to the dynamics of their bacterial hosts. Indeed, many phages have Ig-like binding domains in their structural proteins the capacity to bind to mucins, the large glycoproteins giving the viscous properties for the mucosal surface. This has led to the Bacteriophage Adherence to Mucus -(BAM) hypothesis: eukaryotes accommodate phages on their mucosal surfaces to provide external immunity against bacterial disease. This may have resulted into a symbiotic relationship between metazoans and phages, in which the metazoan host provides phages an environment to encounter bacterial hosts, and phages protect from bacterial infections in this process. We have studied phage binding on mucus and the effect of mucosal environment on phage-bacterium interactions. Our results show that phage adhesion to mucus results in preventive protection against bacterial infections. Interestingly, exposure to mucus upregulates bacterial virulence, which is exploited by phages for infection by increasing infection rate. In response, mucosal environment change the ecology of bacterial resistance against phages by increasing the activity of the CRISPR-Cas adaptation. These results suggest that the traditional co-culture studies may give a biased view on host-associated phage-bacterium interactions, which is strongly influenced by the chemical cues of the metazoan host. This phenomenon might be widespread in the biosphere and thus crucial for understanding mucosal diseases, their outcome and treatment.
Lotta-Riina is an associate professor at the Department of Biological and environmental science, and the Nanoscience Center in Jyväskylä, find out more on her research here:
https://lrsundberg.weebly.com/
The rest of the seminar program for the spring is under construction, but we have a few speakers confirmed already:
https://thursdayseminarbiology.wordpress.com/
See you on Thursday,
Heikki
Heikki Helanterä is inviting you to a scheduled Zoom meeting.
Topic: Biology Thursday seminar
Time: This is a recurring meeting Meet anytime
Join Zoom Meeting
https://oulu.zoom.us/j/62917763539?pwd=WENZRy9Bb3NlSzlyeVlVamJ4RHR5Zz09
Meeting ID: 629 1776 3539
Passcode: 166151
One tap mobile
+496938079883,,62917763539# Germany
+496950502596,,62917763539# Germany
Dial by your location
+49 69 3807 9883 Germany
+49 695 050 2596 Germany
+49 69 7104 9922 Germany
+49 30 5679 5800 Germany
Meeting ID: 629 1776 3539
Find your local number: https://oulu.zoom.us/u/ccTmAGzcv
Join by SIP
62917763539(a)109.105.112.236<mailto:62917763539@109.105.112.236>
62917763539(a)109.105.112.235<mailto:62917763539@109.105.112.235>
Join by H.323
109.105.112.236
109.105.112.235
Meeting ID: 629 1776 3539
Passcode: 166151
===============================================
Heikki Helanterä
Associate Professor (tenure track)
Ekologian ja genetiikan tutkimusyksikkö / Ecology and Genetics Research Unit
Oulun Yliopisto / University of Oulu / Finland
heikki.helantera(a)oulu.fi<mailto:heikki.helantera@oulu.fi>
+358-40-7507 334
Dear colleagues,
I’m putting together the Biology Thursday seminar for the spring, and I need your help – who would you like to see as a speaker? As the seminar is running on zoom for the spring semester, this is a great opportunity to invite speakers without having to worry about travel budgets. So please send me suggestions for speakers, or be prepared for a semester of talks filled with social evolution and ant genomics 😉
As you can see from the program, only very few dates have been set, and there is still plenty of space https://thursdayseminarbiology.wordpress.com/
We will kick off next week with Dr. Lotta-Riina Sundberg with the title ”Is the test tube telling the whole story? Impact of the mucosal environment on phage-bacterium interplay” – her group does super exciting work on evolution and ecology of bacteria and their viruses https://lrsundberg.weebly.com/research.html so this is worth checking out! Reminders and zoom links and all that to follow next week…
All the best,
Heikki