Dear colleagues,
the first Biology Thursday seminar for 2021 is taking place on 21st Jan, at 12.15 via zoom (link below).
The speaker is Dr. Lotta-Riina Sundberg from University of Jyväskylä, on
"Is the test tube telling the whole story? Impact of the mucosal environment on phage-bacterium interplay"
Mucosal surfaces are the first barriers against invading pathogens. However, in addition to immune functions, the outmost layers of mucosal surfaces maintain tissue-specific microbiomes. Viruses, such as bacteriophages are major partners in the microbiomes of the mucosal milieu, contributing to the dynamics of their bacterial hosts. Indeed, many phages have Ig-like binding domains in their structural proteins the capacity to bind to mucins, the large glycoproteins giving the viscous properties for the mucosal surface. This has led to the Bacteriophage Adherence to Mucus -(BAM) hypothesis: eukaryotes accommodate phages on their mucosal surfaces to provide external immunity against bacterial disease. This may have resulted into a symbiotic relationship between metazoans and phages, in which the metazoan host provides phages an environment to encounter bacterial hosts, and phages protect from bacterial infections in this process. We have studied phage binding on mucus and the effect of mucosal environment on phage-bacterium interactions. Our results show that phage adhesion to mucus results in preventive protection against bacterial infections. Interestingly, exposure to mucus upregulates bacterial virulence, which is exploited by phages for infection by increasing infection rate. In response, mucosal environment change the ecology of bacterial resistance against phages by increasing the activity of the CRISPR-Cas adaptation. These results suggest that the traditional co-culture studies may give a biased view on host-associated phage-bacterium interactions, which is strongly influenced by the chemical cues of the metazoan host. This phenomenon might be widespread in the biosphere and thus crucial for understanding mucosal diseases, their outcome and treatment.
Lotta-Riina is an associate professor at the Department of Biological and environmental science, and the Nanoscience Center in Jyväskylä, find out more on her research here: https://lrsundberg.weebly.com/
The rest of the seminar program for the spring is under construction, but we have a few speakers confirmed already: https://thursdayseminarbiology.wordpress.com/
See you on Thursday, Heikki
Heikki Helanterä is inviting you to a scheduled Zoom meeting.
Topic: Biology Thursday seminar Time: This is a recurring meeting Meet anytime
Join Zoom Meeting https://oulu.zoom.us/j/62917763539?pwd=WENZRy9Bb3NlSzlyeVlVamJ4RHR5Zz09
Meeting ID: 629 1776 3539 Passcode: 166151 One tap mobile +496938079883,,62917763539# Germany +496950502596,,62917763539# Germany
Dial by your location +49 69 3807 9883 Germany +49 695 050 2596 Germany +49 69 7104 9922 Germany +49 30 5679 5800 Germany Meeting ID: 629 1776 3539 Find your local number: https://oulu.zoom.us/u/ccTmAGzcv
Join by SIP 62917763539@109.105.112.236mailto:62917763539@109.105.112.236 62917763539@109.105.112.235mailto:62917763539@109.105.112.235
Join by H.323 109.105.112.236 109.105.112.235 Meeting ID: 629 1776 3539 Passcode: 166151
=============================================== Heikki Helanterä Associate Professor (tenure track) Ekologian ja genetiikan tutkimusyksikkö / Ecology and Genetics Research Unit Oulun Yliopisto / University of Oulu / Finland heikki.helantera@oulu.fimailto:heikki.helantera@oulu.fi +358-40-7507 334