Dear colleagues,

Biology Thursday seminar continues on 5th Oct, 12:15 on zoom (link below) with Dr. Ilkka Kronholm, University of Jyväskylä, on

"Influence of chromatin structure on spontaneous mutations and methylation changes in a filamentous fungus"

Abstract Everywhere we look, organism are very well adapted to their environments. Adaptation is the result of natural selection, but natural selection needs variation to function and this variation is generated by mutation. While we understand fairly well how natural selection works, our understanding of how variation is generated and what are its properties is more limited. My group studies the properties of genetic and epigenetic variation. Recently we did a mutation accumulation experiment in the filamentous fungus Neurospora crassa to study how chromatin structure influences the mutation rate and what is the rate of spontaneous epigenetic changes in N. crassa. We observed that mutation rate is higher in heterochromatic regions marked by H3K9me3 and H3K27me3. I'll also show some preliminary results regarding spontaneous methylation changes and how chromatin stucture influences recombination. To understand how different processes shape genetic variation across the genome, we can generate better null models to study how natural selection shapes genetic variation.

More on Ilkka's work at: https://www.jyu.fi/science/en/bioenv/staff-and-administration/staff/kronholm... and https://scholar.google.fi/citations?hl=fi&user=zKF9_HoAAAAJ&view_op=...

See you in zoom on Thursday,

Heikki

Heikki Helanterä is inviting you to a scheduled Zoom meeting.

Join Zoom Meeting https://oulu.zoom.us/j/62917763539?pwd=WENZRy9Bb3NlSzlyeVlVamJ4RHR5Zz09

Meeting ID: 629 1776 3539 Passcode: 166151

---

Join by SIP 62917763539@109.105.112.236 . 62917763539@109.105.112.235

---

Join by H.323 . 109.105.112.236 . 109.105.112.235

Meeting ID: 629 1776 3539 Passcode: 166151 ......................................................................................................................................... Join Teams Meeting en-US https://teams.microsoft.com/l/meetup-join/19%3ameeting_MDcyMWM2Y2ItMzIyYi00Y... Meeting ID: 379 611 672 167 Passcode: HB5uZ8

If you need a local number, get one here. And if you've forgotten the dial-in PIN, you can reset it. Toll number: +358 9 85626307 Conference ID: 571 178 854# Local Number : https://dialin.teams.microsoft.com/3842a853-a94d-4f5e-b81d-3786eed9ea69?id=5... Reset Pin : https://dialin.teams.microsoft.com/usp/pstnconferencing

Learn More https://aka.ms/JoinTeamsMeeting | | Meeting options: https://teams.microsoft.com/meetingOptions/?organizerId=e5f6495e-68a8-49c3-9... | .........................................................................................................................................