Crc December 2024

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20 participants
54 discussions

Available slots for researcher profile photo sessions on Wednesday (11 Dec) at Kontinkangas
by Meri Rova 09 Dec '24

09 Dec '24

Dear researchers, There are still available slots for researcher profile photo sessions on Wednesday (11 Dec) at Kontinkangas. The photoshootings are intended for researchers of whom the researcher profile picture has not yet been taken. Please read more on Patio and book your time as instructed: https://patio.oulu.fi/en/events/researcher-profile-photoshoot-12 Best wishes, Meri Rova Viestintäasiantuntija, FT lääketiede Oulun yliopisto, Kontinkankaan kampus, Aapistie 5A meri.rova(a)oulu.fi<mailto:meri.rova@oulu.fi> | 050 464 3361| X @meri_rova

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FibroHUB, December 10
by Ritva Saastamoinen 09 Dec '24

09 Dec '24

Welcome to the monthly FibroHUB, the last one of the year 2024! 10 December at 15-16 Place: Lecture hall F202 (Aapistie 5B) Topic: by Daniel Ungureanu: Setting scRNA-seq technologies for understanding tissue heterogeneity and drug responses Daniela's team<https://www.oulu.fi/en/research-groups/precision-oncology-ovarian-cancer> recently made a scientific breakthrough with their paper in Nature Chemical Biology, which has immediately received a lot of media attention. A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery.<https://pubmed.ncbi.nlm.nih.gov/39482470/> Dini A, Barker H, Piki E, Sharma S, Raivola J, Murumägi A, Ungureanu D. Nat Chem Biol. 2024 Oct 31. doi: 10.1038/s41589-024-01761-8. Online ahead of print.PMID: 39482470 Brief intro to the topic: Single-cell RNA sequencing (scRNA-seq) has become a powerful tool for understanding tissue heterogeneity by profiling gene expression at the single-cell level. This allows for the detection of rare cell types, uncovering cellular diversity, and identifying the molecular signatures of different cell populations and the way these cells respond to perturbations. There are several scRNA-seq technologies that are particularly valuable for exploring transcriptomics at single cell levels. Come to find out! [Coffee with solid fill] Coffee/Tea or Glögi (first come, first serve), casual get-together, timely topic and discussions for community-building and cross-disciplinary dialogue -------------- * Feel free to forward this invitation to your colleagues at the University of Oulu who could be interested to join and register as a new FibroHealth researcher<https://link.webropolsurveys.com/Participation/Public/4c6c14b3-af6e-4352-a5…>. Cheers, Ritva ---------------------------------------------------------------------------------------------------------- Ritva Saastamoinen PhD, Adjunct Professor (Docent) Coordinator, Profi6 Fibrobesity Research Unit of Biomedicine and Internal Medicine (Room S5 230 at University Hospital) Faculty of Medicine University of Oulu tel. +358 294 48 5226, +358 50 592 3333 X: FibroHealthOulu @FibroOulu<https://twitter.com/FibroOulu> & @saastamoiritva<https://twitter.com/FibroOulu> LinkedIn: FibroHealth Oulu & Ritva Saastamoinen<https://www.linkedin.com/in/ritva-saastamoinen-64a97659/> FibroHealth - Combatting Fibrosis in Chronic Diseases | University of Oulu<https://www.oulu.fi/en/fibrohealth-combatting-fibrosis-chronic-diseases> [A close-up of leaves Description automatically generated] FibroHealth Symposium 2024: Bridge over Obesity - From Science to Practice<https://www.oulu.fi/en/events/fibrohealth-symposium-2024-bridge-over-obesit…> November 26, Oulu, Finland<https://www.oulu.fi/en/events/fibrohealth-symposium-2024-bridge-over-obesit…> [cid:image004.png@01DB425F.E9D3A690]

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Ad hoc seminar on Monday Dec.9, at 15.15 in F101 by professor Jian Yan
by Pirkko Huhtala 09 Dec '24

09 Dec '24

Dear all, On Monday December 9 Professor Jian Yan from Northwest University of China & Associate Professor, City University of Hong Kong is visiting Kontinkangas Campus, and he will give an Ad hoc seminar at 15.15. in F101. The title of his presentation is "Decoding the regulators influencing the epigenome". Short CV Dr. Yan received his B.Sc. degree in Biological Sciences at Tsinghua University, China and M.Sc. degree in Biotechnology at University of Helsinki. He continued his Ph.D. study with Prof. Jussi Taipale at Karolinska Institutet, Sweden investigating the molecular mechanism of transcriptional regulation in colorectal cancer. After obtaining the doctor's degree in 2014, Dr. Yan was awarded a prestigious prize for the outstanding oversea graduate students by the Chinese government. Meanwhile, he obtained two postdoctoral fellowships from both the Human Frontier Science Program and the International Postdoc Fellowship of Swedish Research Council (VR) and then he moved to the University of California San Diego to conduct his postdoctoral research on epigenetic regulation of 3D genome organization and gene transcription in Prof. Bing Ren's laboratory. In 2018, he joined the Department of Biomedical Sciences, City University of Hong Kong as a tenure-track assistant professor, and in 2023 he was promoted to associated professor, and meanwhile he had been jointly appointed as a professor to the College of Life Sciences at Northwest University of China. Dr. Yan's primary research interest is to unveil the molecular mechanism of how non-coding genomic elements, including both cis-regulatory DNA elements and non-coding RNAs, participate in the transcriptional regulation. To achieve the goal, he has also developed multiple state-of-the-art genomic tools, such as HT-SELEX, SNP-SELEX, CARPID, Chrom-seq, etc to systematically study the interactions between the non-coding nucleic acids and binding proteins to illustrate their molecular function in the regulation of gene expression. By now, Dr. Yan has supervised more than 20 graduate students and postdocs, and published over 30 peer-reviewed significant scientific articles, mostly in high impact journals, such as Nature, Cell, Nature Methods, as the primary authors with a total citation over 7,000 times (h-index 22; i10-index 28). About his presentation Chromatin epigenetic modifications are enriched at various cis-regulatory elements, essential for spatiotemporal regulation of gene transcription. The epigenetic marks interplay with different trans-regulatory factors, such as transcription factor (TF) and RNA. However, mechanism of the crosstalk has yet to be fully elucidated. In the first half, I'll discuss about the potential mechanism of how DNA methylation is regulated around the binding sites of CTCF, a highly conserved TF involved in 3D genome organization. By leveraging proteomic analysis, we found that multiple subunits of the nucleosome remodeling and deacetylase (NuRD) complex could bridge the interaction between CTCF and the TET DNA demethylases to mediate the CTCF-associated DNA demethylation. More interestingly, we show that chromatin the binding of CTCF heavily depends on the NuRD complex. Depletion of NuRD severely abrogates CTCF binding and leads to destruction of the chromatin high-order structures, revealing a novel role of the NuRD complex in 3D genome organization. In the second half, a novel method termed Chrom-seq to identify chromatin associated regulatory RNAs (carRNA) around various epigenetic marks will be introduced. The method avoids using crosslinking and antibody-mediated capture, and thus substantially enhances the signal-to-noise ratio. By applying Chrom-seq to different cells, we systematically map RNAs at various chromatin marks and validate the regulatory roles of some ncRNAs, endorsing the role of RNA in regulating the epigenome landscape. If you are interested to have discussions with the speaker, please, contact Professor Aki Manninen. Welcome everybody! No registration required. Coffee is served during networking session 20 min before the presentation time. Field specific credits can be earned according to UniOGS recommendations<https://www.oulu.fi/en/research/graduate-school/thesis-requirements-and-stu…> (attendance at scientific seminars for 10 hours: 0,5ECTS) Kind regards Pirkko Pirkko Huhtala, PhD Coordinator Biocenter Oulu, University of Oulu e-mail: pirkko.huhtala(a)oulu.fi<mailto:pirkko.huhtala@oulu.fi> tel: +358-294 486101, + 358-40 1897467 Street address: Room 476B, Aapistie 5A, FIN-90220 Oulu Mailing address: PO Box 5000, FIN-90014 University of Oulu, Finland www.oulu.fi/biocenter<http://www.oulu.fi/biocenter>

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Uudet ERC-tukitoimet vuonna 2025 // New ERC support activities in 2025
by Mirko Maksimainen 05 Dec '24

05 Dec '24

Uudet ERC-tukitoimet vuonna 2025 Lanseeraamme uusia ERC-tukitoimia vuonna 2025, jotta voisimme lisätä Euroopan tutkimusneuvoston ERC-hakemuksissa menestymistämme Oulun yliopistossa. Yksi tärkeimmistä uusista aloitteista on ERC-kiihdyttämö, kolmen työpajan sarja, jonka tarkoituksena on kannustaa nuoria tutkijoita kehittämään kunnianhimoisia ja uraauurtavia tutkimusideoita. Tapaamiset järjestetään helmi-, maalis- ja huhtikuussa 2025, ja niiden aikana keskitytään luovuuteen ja innovatiiviseen ajattelun harjoitteluun. Osallistujat tulevat kuulemaan ERC-rahoitushakujen perustiedot, kuulevat ERC-konsulttiyritys Yellow Researchin inspiroivan esityksen ERC:n hakemuksilta vaadittavasta korkeasta ambitiotasosta sekä tulevat työstämään omia tutkimusideoitaan (ja saavat niihin palautetta tutkimusrahoitusasiantuntijoilta). Osallistujat saavat myös tietoa varsinaisesta ERC-tukiprosessista tulevia hakuja varten. Kiihdyttämöohjelman lisäksi tarjoamme aiempaa enemmän Yellow Researchin ERC-hakemusten arviointeja. Vuonna 2025 tarjoamme tämän arvioinnin kuudelle Starting Grant (StG)-, kuudelle Consolidator Grant (CoG)-, kuudelle Advanced Grant (AdG) -hakijalle ja kahdelle Synergy Grant (SyG) -hakijalle. Lisäksi järjestämme nyt jo toisen kerran rahoituksen saaneiden ERC-hakemusten lukupäivän (27. toukokuuta 2025) yhteistyössä Suomen Akatemian kanssa. Tämä tapahtuma tarjoaa ERC-hakemusta suunnitteleville tutkijoille erinomaisen tilaisuuden lukea onnistuneita hakemuksia ja ammentaa niistä itselle vinkkejä omaan hakemuksen kirjoittamiseen. Jatkamme edelleen myös muita aiempien vuosien tukitoimia, joihin kuuluvat mm. ERC-verkkokoulutus (toukokuussa), säännölliset tapaamiset hakemusten kirjoittamisen tueksi, vertaisarviointimahdollisuudet, ERC konsulttiarvioinnit (Yellow Reseach), graafisen suunnittelun tuki ja paljon muuta. Tutkijoiden, jotka suunnittelevat ERC-hakemusten jättämistä, on hyvä rekisteröityä mukaan ERC-tukiprosessiin hyvissä ajoin, tällöin pystyy hyödyntämään paremmin monia tarjoamistamme tukitoimista. Toivomme, että laajennetulla ERC-tukitoimien valikoimalla voimme tarjota kattavampaa tukea tutkijoillemme ja näin parantamaan Oulun yliopiston ERC-hakemusten kilpailukykyä. Lue lisää ERC-apurahoista on ERC:n verkkosivuilla<https://erc.europa.eu/apply-grant>. Pation ERC-sivultamme<https://patio.oulu.fi/fi/palvelut-ja-ohjeet/tutkimuksen-tuki/rahoituslahtee…> löytyy lisätietoja ERC-tukiprosessista. *** Täytä tämä rekisteröintilomake<https://link.webropol.com/s/ercoulu> rekisteröityäksesi ERC-tukiprosessiin. (Suosittelemme, että tutkijat aloittavat ERC-hakemustensa suunnittelun kuusi kuukautta ennen kyseisen haun sulkeutumista). https://patio.oulu.fi/fi/uutiset/uudet-erc-tukitoimet-vuonna-2025 New ERC support activities in 2025 To increase our success with European Research Council (ERC) applications, the University of Oulu is excited to announce several new initiatives for 2025. One of the key initiatives is the ERC Accelerator Programme, a three-session programme designed to encourage young researchers to develop ambitious and groundbreaking application ideas. The sessions will take place in February, March, and April 2025 and include activities focused on creativity and innovative thinking. Participants will receive an introduction to the ERC, hear an inspirational speech from Yellow Research on the high standards required for ERC applications, and work on their own research ideas with feedback from Research Funding Specialists. Participants will also learn about the actual ERC support process for future applications. In addition to the Accelerator Programme, we are offering more ERC consultancy slots for application reviews from Yellow Research in 2025. These slots include six for Starting Grant (StG), six for Consolidator Grant (CoG), six for Advanced Grant (AdG), and two for Synergy Grant (SyG) applications. We are also planning to host a Successful ERC Applications Reading Day for the second time in Oulu (on May 27th, 2025). This event will offer applicants an excellent opportunity to see what successful ERC applications look like. Furthermore, we will continue other support activities from previous years, such as online ERC training, regular meetings to support application writing, peer review possibilities, ERC consultancy reviews, graphic design support, and more. Researchers planning to submit their ERC applications should register early in our ERC support process to benefit from all support activities. Implementing these ERC support activities will allow us to provide comprehensive support to our researchers and enhance the competitiveness of their ERC applications. To learn more about ERC grants, visit the ERC website<https://erc.europa.eu/apply-grant>. Our specific ERC Patio page<https://patio.oulu.fi/en/services-and-instructions/research-support/funding…> provides more details about our ERC support process. *** Please complete this registration form<https://link.webropol.com/s/ercoulu> to register for the ERC support process. (We recommend researchers start planning their ERC applications six months before the call deadlines.) https://patio.oulu.fi/en/news/new-erc-support-activities-2025

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Snellman säätiön apurahailmoitus (haku 1.1. - 31.1.2025)
by Mirko Maksimainen 05 Dec '24

05 Dec '24

Hei, Välitän tiedon Snellman säätiön tulevasta apurahahausta (liitteenä) 1.1. - 31.1.2025. ********** Dear all, The attached information of the upcoming call of grants by the Snellman foundations is only available in Finnish Terveisin / Best wishes, Mirko ______________________________________________ Mirko Maksimainen, FT | PhD. Tutkimusrahoitusasiantuntija | Research Funding Specialist Tutkimus- ja Projektipalvelut | Research and Project Services Oulun yliopisto | University of Oulu Tel. +358 29 448 5414 Mobile +358 50 479 2506 ________________________________

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Alueellinen koulutuspäivä tutkimushoitajille 28.1.2025 klo 12–15
by Reetta Hinttala 05 Dec '24

05 Dec '24

Hei, Koulutuspäivä on tarkoitettu tutkimushoitajille, tutkijoille ja muille aiheesta kiinnostuneille. Paikka: OYS, vanha sairaala, Luentosali 4, Kajaanintie 50, 90220 Oulu Alueellinen koulutuspäivä tutkimushoitajille 28.1.2025 klo 12–15 Ohjelma: Klo 12.00–12.30: Tutkijan työpöytä Minna Mäkiniemi, tutkimuspäällikkö, Tutkimuspalvelut Klo 12.30–13.30: Tutkimushoitajan työnkuva Heidi Häikiö, tutkimushoitaja, klo 12.30 –12.50 Henna Pihlajaniemi, tutkimushoitaja, klo 12.50–13.10 Riitta Vikeväinen, tutkimushoitaja, klo 13.10–13.30 Klo 13.30–14.00: Polku poikkitieteelliseksi tutkijaksi Heikki Huhta, erikoislääkäri, gastrokirurgian dosentti Klo 14.00–14.30: Kahvitarjoilu ja verkostoitumista Klo 14.30–15.00: Sydänperäinen äkkikuolema tutkimuksen kohteena Juhani Junttila, kardiologian professori, ylilääkäri Koulutus on maksuton. Ei ilmoittautumista. From: Seljänperä Seija <seija.seljanpera(a)pohde.fi> Sent: tiistai 3. joulukuuta 2024 14.18 To: Reetta Hinttala <reetta.hinttala(a)oulu.fi> Subject: Tutkimuspalveluiden opintopäivä Heissan Reetta, ohessa Tutkimuspalveluiden opintopäivän ohjelma tammikuulle - saa jakaa vapaasti. Tervetuloa kaikki kiinnostuneet, mitään ei maksa ja kyllä me varmaan kahvitkin tarjotaan. Seija / Koe-eläinkeskus 0401258962

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Paloilmoitinjärjestelmän palokellojen testaukset / Fire alarm system bells testing
by Antti Haapalainen 05 Dec '24

05 Dec '24

Palokellojen testaus suoritetaan aamuisin 9.12.-13.12.2024 välisenä aikana. Tästä johtuen palokellot soivat lyhyitä aikoja, mutta tämä ei aiheuta toimenpiteitä asiakkaille. Kontinkangas * Apistie 5, Kieppi 9.12. klo 6-7 * KEKS 10.12. klo 6-7 * Aapistie 7 11.12. klo 6-7 Fire alarms will be tested on the morning between 9.12.-13.12.2024. This will cause the fire bells ring for short periods of time but please note that this won´t result in any actions. Kontinkangas * Aapistie 5, Kieppi 9.12. 6-7 * KEKS 10.12. 6-7 * Aapistie 7 11.12. klo 6-7

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Research plan seminar of Research Unit of Population Health
by Nina Rautio 05 Dec '24

05 Dec '24

Dear all, Welcome to the Research plan seminar of Research Unit of Population Health! The seminar is being held on 11th of December at 14-16 in Room P117 (Kontinkangas Campus, Aapistie 5B) and in Zoom https://oulu.zoom.us/j/63141828799 Meeting ID: 631 4182 8799 In the seminar, doctoral researchers will present their PhD research plans. The seminar is open for everyone, and no registration required for participation. The event is held in English. Seminar program 14.00-14.20 Luoma, Ulla-Maija Research plan: The association between the characteristics of the natural, built and socio-economic environment of the home and daycare center with children's movement, sitting still and sleep SUNRISE Oulu and NFBC1986 studies Research Unit: Research Unit of Population Health Supervisor: Raija Korpelainen 14.20-14.40 Kilpivaara, Katariina Research plan: Breast hypertrophy: prevalence, symptoms and correlation to hormonal status Research Unit: Research Unit of Translational Medicine Supervisor: Tero Rautio 14.40-15.00 Salo, Ville Research plan: Genetic landscape of musculoskeletal disorders Research Unit: Research Unit of Health Sciences and Technology Supervisor: Johannes Kettunen 15.00-15.20 Tirkkonen, Otso Research plan: Comparision oral health status and associated factors among two birth cohorts in Northern Finland (NFBC1966 and NFBC1986) Researh Unit: Research Unit of Population Health Supervisor: Saujanya Karki 15.20-15.40 Takala, Jasmin Research plan: The genetic and epidemiological linkage between different women's diseases studied either with the methods of GWAS or classical epidemiology by using international and national biobank resources and health register data Research Unit: Research Unit of Population Health Supervisor: Outi Uimari 15.40-16.00 Lahtinen, Topi Research plan: Keratoconus treatment with corneal collagen cross-linking (CXL) at Oulu university hospital Research Unit: Research Unit of Clinical Medicine Supervisor: Nina Hautala Welcome! Nina Rautio Projektikoordinaattori, Dosentti Väestöterveyden tutkimusyksikkö Lääketieteellinen tiedekunta PL 5000 90014 Oulun yliopisto (käyntiosoite Aapistie 5B) Project Coordinator, Docent Research Unit of Population Health Faculty of Medicine P.O. Box 5000 FIN-90014 University of Oulu Finland Mobile: +358 40 672 4344

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Terävistä esineistä/About sharp objects
by Salla Kangas 04 Dec '24

04 Dec '24

Hei kaikille, Vähän vakavammalla asialla olen nyt liikkeellä: muistutus käytettyjen skalpellien ja neulojen, sekä muiden terävien esineiden säilytyksestä. Ei ikinä näin, kuten kuvassa (kynien ja muun tavaran seassa!). Tänään sattui (onneksi pieni) tapaturma tämän seurauksena. Nämähän on kertakäyttöisiä, eli jos ei ole kunnollista ja turvallista teräsuojaa ja varmasti turvallista säilytyspaikkaa noille, nuo kannattaisi laittaa tuollaiseen takana näkyvään terävien esineiden roskikseen (keltainen astia kuvan taka-alalla). Se on kuitenkin aika pieni hinta siitä, ettei kenenkään tarvitse miettiä että mitähän kemikaalia tuli vahingossa sormeen työtä tehdessä pistettyä (tai ikävämpiäkin ne seuraukset voi olla). Pidetään siis työympäristö turvallisena ja terveellisenä kaikille, kiitos. -------- Dear all, A bit more serious message today for all: Reminder about the storage of used scalpels, needles, and other sharp objects. Never, ever like this, as shown in the picture (next to pencils and other stuff). An accident happened today as a result of this. These are single-use, so if there's no proper and safe needle cap, these should be placed in the sharps waste bin, like seen at the back of the picture (yellow bin). It's a small price to pay to ensure that no one has to worry about accidentally getting a chemical-contaminated prick on their finger while working (or worse). Let's keep the work environment safe and healthy for everyone, thank you. Terveisin/Kind Regards, Salla Salla Kangas, Postdoctoral researcher Clinical Research Center (CRC) Pediatric Neurology team Research Unit of Clinical Medicine Faculty of Medicine, University of Oulu, Finland -------------------------------------------- P.O. Box 5000 (Aapistie 5A) 90220 Oulu, Finland -------------------------------------------- Office 352B/Kieppi building

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Karaoke-pikkujoulut/ Karaoke Christmas party
by Riikka Arffman 03 Dec '24

03 Dec '24

Tip tap, tip tap, tipe tipe tiptap! Järjestämme perjantaina 13.12. klo 16 alkaen CRC:n vapaamuotoiset karaokepikkujoulut. Kaikki ovat tervetulleita, ikään, laulutaitoon ja tai äidinkieleen katsomatta. Lauluvalikoima on laaja. Tarjoilut ja juomat nyyttäriperiaatteella. Tervetuloa! Riikka ja joulutontut Jingle bells, jingle bells! On Friday the 13th of December we will organize a casual karaoke-themed Christmas get-together in the CRC coffee room at 4 p.m. Everyone is welcome, despite their age, musical talent, or language. There will be a wide variety of songs in a wide variety of languages. Pot luck, so everybody brings something to snack or drink. Welcome! Riikka and the elves Riikka K. Arffman, PhD, Post-doctoral researcher for the Profi6 Fibrobesity, Research manager, Terhi Piltonen Group, Department of Obstetrics and Gynecology Research Unit of Clinical Medicine University of Oulu 90014 Oulu, FINLAND Contact: e-mail: riikka.arffman(a)oulu.fi<mailto:riikka.arffman@oulu.fi>

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