Dear all,

The Biocenter Oulu Discovery of the Year 2025 Event was held on December 15.

BCO Discovery of the year 2025:

Orexin effect on physiological pulsations of the human brain.

Proc Natl Acad Sci U S A. 2025 Aug 5;122(31):e2501578122

Järvelä M, Kananen J, Helakari H, Korhonen V, Huotari N, Väyrynen T, Hautamäki K, Raitamaa L, Tuunanen J, Kallio M, Piispala J, Ansakorpi H, Kiviniemi V.

Presentation by Matti Järvelä

The Best Poster 2025 voted by the audience:

MauE, a new disulfide bond formation pathway

Cassandra P. Gonzalez, Antti Moilanen, Kati Korhonen, Thu Nguyen Pham Anh, Joonatan Hiltunen and Lloyd W. Ruddock

Presented by Cassandra Gonzalez

Congratulations!

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The other publications presented in the event were the following (not in the ranked order):

Ccer1 is a spermatid-specific gene required for spermatogenesis and male fertility.

Int J Dev Biol. 2024;68(4):251-262

Sammer B, Schmid P, Miyata H, Kazi S, Honkimaa AL, Petrov P, Kapiainen E, Miinalainen I, Izzi V, Ikawa M, Prunskaite-Hyyryläinen R.

Presentation by Bianca Sammer

Pulmonary Aspergillosis and Low HIES Score in a Family with STAT3 N-Terminal Domain Mutation.

J Clin Immunol 2025 Feb 10;45(1):73.

Lima de Souza S, Asano T, Glumoff V, Keskitalo S, Pikkarainen K, Martelius T, Kaustio M, Saarela J, Kuismin O, Lappi-Blanco E, Jartti A, Yannopoulos F, Tiitto L, Seppänen MRJ, Boisson B, Casanova JL, Varjosalo M, Hautala T, Chen Z.

Presentation by Keela Pikkarainen

The glycosaminoglycan chains of perlecan regulate the perivascular fluid transport.

Fluids Barriers CNS. 2025 May 8;22(1):48

Singh A, Kaakinen M, Elamaa H, Kiviniemi V, Eklund L.

Presentation by Mika Kaakinen

Targeting HIF-P4H-2 in APP/PS1 Alzheimer's mouse model improves glucose metabolism, reduces dystrophic neuritis, and maintains exploratory activity.

J Biol Chem. 2025 Aug;301(8):110432

Kurkela M, Dvořáková L, Koivisto H, Uusitalo M, Kursula P, Kettunen M, Gröhn O, Tanila H, Koivunen P.

Presentation by Margareta Kurkela

Discovery of Inhibitors for Bacterial Arr Enzymes ADP-Ribosylating and Inactivating Rifamycin Antibiotics.

ACS Chem. Biol. 2025, 20, 1584−1593

Alaviuhkola J, Abdulmajeed S, Sowa ST, Pääkkönen J, Lehtiö L.

Presentation by Juho Alaviuhkola

Congratulations!

Wishing you all a relaxing holiday season!

Best wishes,

Mirja

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Mirja Peltola, PhD, BSc (Tech.)

Oulun yliopisto | University of Oulu

Biocenter Oulu

Cofund MSCA Data4Healthcare Programme

Programme Manager, Coordinator

Tel. +358 294 48 5447

PO Box 5000, FI-90014 OULUN YLIOPISTO

(Aapistie 5A, Room 476B)