Dear laboratory animal researchers
Karolinska Institute’s laboratory animal science webinar on Friday, 01 December, describes strategies for maximizing experimental signal and reducing noise in your experiments. See below more detailed information and registration instructions.
Note that the number of attendants in these Karolinska Institute webinars is limited. Persons not affiliated to KI or to any of the sponsors listed in the registration form may be let out if there are too many participants.
Best regards,
Sakari
Sakari Laaksonen Designated veterinarian Oulu Laboratory Animal Centre (OULAC) University of Oulu, Finland Postal address: PO Box 5000, 90014 University of Oulu, Finland Tel: +358 294 48 5097
Aihe: LAS CPD webinar | “Reduction by Design: Three Statistical Principles for Minimising Animal Use” | Friday, 1 December 2023, 2 PM CET
Dear colleague,
Registration is open for the free webinar “Reduction by Design: Three Statistical Principles for Minimising Animal Use” which will be presented by Penny S. Reynolds, Ph.D., Assistant Professor, Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Date: Friday, 1 December 2023, Stockholm 2 PM CEThttps://time.is/CET
ABSTRACT
Reduction of animal numbers is one of the three pillars of the 3Rs, but – paradoxically - is often perceived as conflicting with the goal of maximizing statistical power. However, a large sample size does not guarantee adequate power, and high power does not ensure that results are informative. Based on Ronald Fisher’s concept of statistical information, I outline three statistically-based but non-technical strategies for maximizing experimental signal and reducing noise. These include a clear statement of the research question, statistically-structured study design, and variance minimisation. These statistical process basics were developed almost a century ago, and were clearly described by Russell and Burch in 1959. However, most researchers seem to be completely unaware of their existence, and research quality is still poor. Too-small, noisy, and biased studies are uninformative and waste animals. It is our shared responsibility to promote well-established best practice standards, and emphasise appropriate design of experiments over statistical significance.
SPEAKER Penny S. Reynoldshttps://anest.ufl.edu/profile/reynolds-penelope/ is an Assistant Professor of Anesthesiology, a wildlife biologist, a statistics expert, a 3Rs advocate, and an author. She has received the UK LASA-Animals in Science Education Trust 3Rs Prize, and the AAALAC Global 3Rs Award. She was one of the co-authors of the ARRIVE 2.0 Reporting Guidelines and Explanation and Elaboration document. Her book “A Guide to Sample Size for Animal-based Studies” is scheduled for release in November 2023.
Register herehttps://websurvey.textalk.se/start.php?ID=146263 (by November 30, 16:00 CET)
Best wishes,
Rafael
___________________________________ Rafael Frías DVM, MSc, PhD, Assoc. Prof. Head, Department of Comparative Medicine (AKM) Named Animal Care and Welfare Officer (NACWO) Karolinska University Hospital (Solna) Anna Steckséns 53, L1:U1 | 171 76 Stockholm, Sweden +46 70167-1632 | rafael.frias-beneyto@regionstockholm.semailto:rafael.frias-beneyto@regionstockholm.se Karolinska Experimental Research and Imaging Centre (KERIC)https://ki.se/en/research/karolinska-experimental-research-and-imaging-centre-keric __________________________________________
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