Post doc position in a research project headed by Professor Peppi Karppinen (Koivunen) in the ECM & Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland.
Our research focuses on the enzyme family of 2-oxoglutarate-dependent dioxygenases and their potential as therapeutic targets. Our main interests are in the hypoxia-inducible factor prolyl 4-hydroxylases, P4H-TM and histone demethylases. We offer a research environment with excellent technological facilities and a motivating and supporting community. A successful candidate possesses a PhD degree preferably in the field of biochemistry, molecular or cell biology, medical science or related fields, and has experience from recombinant protein production and purification, enzyme kinetic analyses and structural biology (crystallization, cryoEM). Prior knowledge of the research field is considered an advantage. More information: https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&i...
Recent publications:
Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019 Mar 15;363(6432):1217-1222.
Laukka T, Myllykoski M, Looper RE, Koivunen P. Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. J Mol Biol. 2018 Sep 14;430(18 Pt B):3081-3092.
Rahikkala E, Myllykoski M, Hinttala R, Vieira P, Nayebzadeh N, Weiss S, Plomp AS, Bittner RE, Kurki MI, Kuismin O, Lewis AM, Väisänen ML, Kokkonen H, Westermann J, Bernert G, Tuominen H, Palotie A, Aaltonen L, Yang Y, Potocki L, Moilanen J, van Koningsbruggen S, Wang X, Schmidt WM, Koivunen P, Uusimaa J. Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome). Genet Med. 2019 Oct;21(10):2355-2363.
Peppi Karppinen (Koivunen), MD, PhD Professor, Dean University of Oulu Faculty of Biochemistry and Molecular Medicine Room L203 │ Aapistie 7A │FIN-90014 University of Oulu FINLAND _____________________________________________ Email peppi.karppinen@oulu.fimailto:peppi.karppinen@oulu.fi Phone +358 (0) 294 485822 [cid:image001.jpg@01D5DCCC.848E3910] Follow us on Facebookhttps://www.facebook.com/unioulu/, Instagramhttps://www.instagram.com/unioulu/?hl=fi, Linkedinhttps://www.linkedin.com/school/university-of-oulu/ and Twitterhttps://twitter.com/unioulu. The content of this message is confidential. If you are not a recipient indicated or intended in this message or you think this message may have been addressed to you in error, please inform us by an email reply and then delete the message. In such case it is forbidden to copy, forward, or in any way reveal the contents of this message to anyone.
