Dear all, 

It is our great pleasure to announce next BCO seminars by Dr. Vincent Prevot:

### SOME INFO ABOUT VINCENT PREVOT ###

Vincent Prevot, Director of Research, Ph.D. in Neuroscience, University of Lille, France

Head of the Inserm Research Team “Development and Plasticity of the Postnatal Brain”, Inserm U837, Jean-Pierre Aubert Research Centre. Lille, France

The research undertaken in Vincent Prevot Laboratories uses a combination of genetic, primary cell culture and co-culture, biochemical, electrophysiological, neuroanatomical, immunofluorescent, electron microscopy, advanced imaging techniques and physiological approaches.

The research focuses on the study of:

-       Neuronal-glial-endothelial communication processes regulating GnRH neurosecretion,

-       endothelial and neuronal nitric oxide signaling, glial erbB signalling,

-       onset of puberty, ovarian cycle-induced brain plasticity and reproduction.

In parallel, Vincent Prevot’s research has interest in studying the role of peripheral hormones (estrogen, leptin, insulin…) on hypothalamic development and function as well as in determining the importance of non-neuronal cells (tanycytes, astrocytes and endothelial cells) in the communication between the peripheral organs and the central nervous system.

Finally, the researches also evaluate how pathologies (such as obesity, diabetes) may affect these neurobiological events and, conversely, how impairment of brain communication with the periphery renders the organism prone to develop pathologies (obesity, diabetes, precocious and/or delayed puberty, and infertility). 

Some selected recent literature from Vincent Prevot and Colleagues^1-3:

(1) Balland E, Dam J, Langlet F, et al. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab 2014; 19: 293-301.

(2) Giacobini P, Parkash J, Campagne C, et al. Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A. PLoS Biol 2014; 12: e1001808.

(3) Langlet F, Levin BE, Luquet S, et al. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab 2013; 17: 607-17.