The Biocenter Oulu Discovery of the Year 2021 event was held on December 15, 2021 remotely.

We had high hopes for a real event with posters … but maybe next year.

Discovery of the year 2021:

Presented by Joona Tapio
Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia.

Auvinen J, Tapio J, Karhunen V, Kettunen J, Serpi R, Dimova EY, Gill D, Soininen P, Tammelin T, Mykkänen J, Puukka K, Kähönen M, Raitoharju E, Lehtimäki T, Ala-Korpela M, Raitakari OT, Keinänen-Kiukaanniemi S, Järvelin MR, Koivunen P.

Sci Adv. 2021 Jul 14;7(29):eabi4822. doi: 10.1126/sciadv.abi4822. Print 2021 Jul.PMID: 34261659

The other publications presented in the event were the following (not in the ranked order):

Cardiovascular brain impulses in Alzheimer's disease.

Rajna Z, Mattila H, Huotari N, Tuovinen T, Krüger J, Holst SC, Korhonen V, Remes AM, Seppänen T, Hennig J, Nedergaard M, Kiviniemi V.

Brain. 2021 Aug 17;144(7):2214-2226. doi: 10.1093/brain/awab144.PMID: 33787890

Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism.

Karpale M, Käräjämäki AJ, Kummu O, Gylling H, Hyötyläinen T, Orešič M, Tolonen A, Hautajärvi H, Savolainen MJ, Ala-Korpela M, Hukkanen J, Hakkola J.

Br J Pharmacol. 2021 Jun;178(12):2461-2481. doi: 10.1111/bph.15433. Epub 2021 May 14.PMID: 33687065

Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition.

Obaji E, Maksimainen MM, Galera-Prat A, Lehtiö L.

Nat Commun. 2021 Jun 9;12(1):3479. doi: 10.1038/s41467-021-23800-x.PMID: 34108479

Exome sequencing identifies a recurrent variant in SERPINA3 associating with hereditary susceptibility to breast cancer.

Koivuluoma S, Tervasmäki A, Kauppila S, Winqvist R, Kumpula T, Kuismin O, Moilanen J, Pylkäs K.

Eur J Cancer. 2021 Jan;143:46-51.

Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis.

Sliz E, Huilaja L, Pasanen A, Laisk T, Reimann E, Mägi R; FinnGen; Estonian Biobank Research Team, Hannula-Jouppi K, Peltonen S, Salmi T, Koulu L, Tasanen K, Kettunen J.

J Allergy Clin Immunol. 2021 Aug 27;S0091-6749(21)01303-8. doi: 10.1016/j.jaci.2021.07.043

Congratulations to all research teams!

Wishing you All relaxing and safe Christmas and Happy New Year 2022 !

Teija Luoto, Management assistant

Biocenter Oulu, University of Oulu

Tel. +358 2 9448 6103

Street address: Aapistie 5A, 90220 Oulu, Finland

Mail address: P.O. Box 5000, FI-90014 University of Oulu, Finland

URL: http://www.oulu.fi/biocenter

www.oulu.fi

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