Information on a course in Uppsala in two parts (September and March). This
probably overlaps (partly) with the course in Oulu last December. Pekka
>Graduate course: Analysis of sequence data (in two parts).
>
>Part I: Basic coalescent theory (Paul Joyce, University of Idaho, USA, and
>Martin Lascoux, EBC). September 6-10 2004
>Part II: Applications (Gil McVean, University of Oxford, UK and Martin
>Lascoux, EBC). Spring 2005. Tentative date: 14/3-17/3 (this may change
>later on).
>
>Credits: 4 points (2 for attendance + 2 for homework). If only one part is
>attended 2 points.
>
>Aim of the course: Introduce the necessary theoretical background to carry
>out the analysis of DNA sequence data (part 1) and go through various
>applications (estimation of population recombination rate, detection of
>recombination hotspots, detection of selection, estimation of past
>demographics, part 2).
>
>Target group: Students studying evolutionary biology in general,
>especially those using genetics. The course will also be relevant for
>students working in gene mapping.
>
>Recommended background: Basic knowledge of genetics, basic knowledge
>of basic probability and statistics
>
>Content: Lectures, Exercises, Computer based assignments. Simulation and
>analysis of empirical datasets.
>
>Preliminary outline:
>
>Part I
>Intro, basic probability, stochastic processes, statistics.
>The standard coalescent
>Estimation of parameters. Computationally simple methods.
>Estimation of parameters. Computationally intensive methods
>Extension of the coalescent: Recombination and selection graphs
>
>Part II
>The coalescent: a reminder
>Modelling and detecting selection
>Recombination: Estimating the population recombination rate
>LD and haplotypes. Haplotype blocks
>Association mapping
>
>Registration: Send an email to Martin Lascoux at Martin.Lascoux(a)ebc.uu.se
>before August 1. You can register for only one part, but I strongly
>recommend attending both as they complement each other. For those coming
>from other universities please note that we do not arrange housing.
>
>Both Paul and Gil are outstanding teachers. Paul already gave a course at
>the EBC a few years ago along the same lines. Here is one of the many
>positive comments on the course: "cheers for a great course which gave me
>lots of ideas for analysing data and thinking about polymorphism. As I
>mentioned at the time, I really wish I had gone to such a course when I
>was a postgrad" (one of the postdoctoral fellow that attended the course).
>
>Welcome!
>
>Martin
>
>Martin Lascoux
>Program in Conservation Biology & Genetics
>Evolutionary Biology Centre
>Uppsala University
>Norbyvägen 18D 752 36 UPPSALA
>SWEDEN
>
>Tel: 46 18 471 64 16
>Fax: 46 18 471 64 24