The Fagerholm group at the Biotechnology Institute, University of Helsinki is seeking to recruit a PhD student. The student will participate in investigations of leukocyte migration. The successful applicant will have the opportunity to develop an independent project within the scope of the core research interests of the lab.
Description
The Fagerholm group consists of Immunologists and Biochemists working together to understand the molecular mechanisms which regulate leukocyte adhesion, migration and signalling in vitro and in vivo. We have developed methodology which allows the study of these processes in the laboratory. In addition, we are interested in the role of integrins in immune system regulation and in immune-system related diseases such as immunodeficiency, autoimmunity and allergy.
Applicants should possess an excellent academic record. In addition, they should have a strong understanding of basic principles of immunology and/or cell and molecular biology and have the ability to work productively both independently and as part of a team.
Interested persons should send their application to Dr. Susanna Fagerholm (susanna.fagerholm(a)helsinki.fi<mailto:susanna.fagerholm@helsinki.fi>), including a brief statement of research interests, a CV (with subjects and degrees), and the names and contact details of 2 referees.
Deadline for application is February 8th 2015, but review of applications will begin immediately and continue until the position is filled.
For an outline of the group's research: http://www.biocenter.helsinki.fi/bi/fagerholm/index.html
Recent publications from the lab include:
1. Morrison VL, James MJ, Grzes K, Cook P, Glass DG, Savinko T, Lek HS, Gawden-Bone C, Watts C, Millington OR, MacDonald AS, Fagerholm SC. (2014). Loss of beta2-integrin-mediated cytoskeletal linkage reprograms dendritic cells to a mature migratory phenotype. Nat Commun. 5: 5359.
2. Gawden-Bone C, West M, Morrison VL, Edgar A, Dill B, Trost M, Prescott A, Fagerholm S, and Watts C (2014). A critical role for beta2 integrins in podosome formation, dynamics and TLR-signalled disassembly in dendritic cells. J Cell Sci, 127:4213-24.
3. Morrison VL, Macpherson M, Savinko T, Lek HS, Prescott A, Fagerholm SC. (2013). The beta2-integrin-kindlin-3 is essential for T cell homing but dispensable for T cell activation in vivo. Blood, 122(8):1428-36.
4. MacPherson, M, Lek, HS, Prescott, A and Fagerholm SC. (2011). A systemic lupus erythematosus-associated R77H substitution in the CD11b-chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis. J. Biol. Chem. 286(19):17303-10.
From: Robinson,Christopher [mailto:christopher.robinson@imp.ac.at]
Sent: 8. tammikuuta 2015 16:33
To: Robinson,Christopher
Subject: Vienna Biocenter Summer School - Open for Applications Now - Calling for Finnish Applicants!
Importance: High
Dear Colleagues
Please find attached a poster advertising our summer school which I would ask you to pass on to any students that you feel might be interested. We would especially like to attract more candidates from Finland.
Further details are available at the following website: www.vbcsummerschool.at<http://www.vbcsummerschool.at> or you can contact me directly for further information
Thanks in advance.
Kind regards from Vienna, Chris
Christopher Robinson
VBC Summer School Administrator
Research Institute of Molecular Pathology (IMP)
Vienna Biocenter (VBC)
Dr. Bohr-Gasse 7
A-1030 Vienna
Austria
Tel.: +43 1 797 30/3001
e-mail: robinson(a)imp.ac.at<mailto:robinson@imp.ac.at>
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Institute for Molecular Medicine Finland (FIMM) is an international research institute in Helsinki (www.fimm.fi<http://www.fimm.fi/>) focusing on human genomics and personalized medicine. FIMM integrates molecular medicine research, technology center and biobanking infrastructures promoting translational research and adoption of personalized medicine in health care. FIMM researchers are involved in several grand challenge projects, such as the impact of genome information from the Finnish population in personalized health and medical interventions, development of individualized cancer medicine, and novel diagnostics via imaging of tissue and cells.
In the areas of bioinformatics and computational systems biology, FIMM collaborates with Helsinki Institute for Information Technology HIIT (www.hiit.fi<http://www.hiit.fi/>), a multi-disciplinary research institute focused on basic and applied research on information technology. Modern molecular medicine requires state-of-the-art methodologies in the analysis, visualization and modelling of large data sets; HIIT groups provide world-class excellence in these areas.
The Neuroscience Center (NC) is an independent research and educational institute (www.helsinki.fi/neurosci<http://www.helsinki.fi/neurosci>), conducting multidisciplinary research on the development, normal functions and disorders of the nervous systems. The NC focus areas include molecular and cellular neuroscience, developmental neuroscience, cognitive and systems neuroscience, and basic research of the nervous system diseases.
FIMM, HIIT, and NC work together with the University of Helsinki Doctoral School in Health Sciences and doctoral programs (http://www.helsinki.fi/health/) and Helsinki Doctoral Education Network in Information and Communications Technology (HICT) to provide excellent research training aimed at a doctoral degree at the University of Helsinki or Aalto University.
FIMM, HIIT, and NC announce the opening of the annual FIMM-EMBL International PhD call for applications. Doctoral student positions in the fields of molecular medicine, bioinformatics, computational systems biology and biomedicine, and neuroscience are now open.
Outstanding doctoral candidates are recruited to an institute-level rotation program where students work with 2-3 different research groups during a 6-9 month period prior to selecting a research group in which to remain for their complete doctoral studies. This program gives students an exciting opportunity to explore different research topics and working environments as well as learn a variety of science and technologies and make connections within and beyond the institute.
Detailed information regarding the institutes, positions, research areas, qualifications, and application and selection process that can be found through FIMM's Open Positions page: https://www.fimm.fi/en/open-positions .
Applications are to be submitted via the online form provided on the Open Positions page no later than February 20, 2014, at 23.59.
Eikö joulupukki tuonutkaan sinulle uutta seinäkalenteria? Ei hätää! Ensi
viikolla sinulla on jälleen tilaisuus lunastaa ihkaomaksi upea LUTKa-
kalenteri! Myyntipiste sijoittuu perinteisesti vihreiden naulakoiden
läheisyyteen tiistaina 13.1. klo 10-14. Kalenterin hinta on 10 euroa.
Mikäli olet maksanut summan jo tilille, otathan mukaan myös kuitin. Tulehan
siis kipinkapin hakemaan omasi ennen kuin loput kalenterit viedään käsistä!
Kalenterin voi maksaa etukäteen tilille (ota tällöin kuitti tai muu
todistus maksusta mukaan) tai käteisellä paikan päällä.
Tilille maksua varten maksuohjeet ovat tässä:
Saaja: Oulun Luonnontieteilijät ry
Tili: FI48 5741 3620 1423 46
Viesti: Kalenteri / kappalemäärä
Summa: 10e per kalenteri
--
-Marko Saari
_______________________________________________
OLuT-tiedotus mailing list
OLuT-tiedotus(a)lists.oulu.fi
http://lists.oulu.fi/mailman/listinfo/olut-tiedotus
Research focus on novel ER located growth factors MANF and CDNF.
One fully funded PhD student position is available under supervision of Prof. Mart Saarma and Dr. Maria Lindahl at the Institute of Biotechnology, University of Helsinki. Further information about the research group and the research topic can be found at http://www.biocenter.helsinki.fi/bi/saarma/ .
We study the structure, biology and therapeutic potential of novel ER located neurotrophic factors CDNF that we have discovered and related protein MANF. We use highly integrative approaches to study MANF and CDNF functions at the molecular, neuronal, and behavioral levels. We have recently developed MANF and CDNF deficient mice and we are now focusing on the role of MANF and CDNF in the development and maintenance of the nervous system.
Aims of the proposed projects include:
1) Characterizing midbrain dopamine system in MANF-conditional knockout mice
2) Analysis of the midbrain dopamine system in CDNF-MANF double knockout mice
3) Dissecting the role of MANF in cerebellum
Applicant should possess a strong understanding in basic principles of neuroscience. Additional desirable qualities include basic mouse knockout technologies, methods in culturing cells and primary neurons and various biochemical and immunological assays or at least willingness to acquire them. Additionally the PhD student will learn behavioral assays, mouse models of Parkinson´s disease, quantification of the number of neurons and measurement of dopamine metabolites. Interested candidates should send their 1-3 page letter of interest, CV and 2 letters of recommendation to Dr. Maria Lindahl (maria.lindahl(a)helsinki.fi<mailto:maria.lindahl@helsinki.fi> ).
Important publications by the group concerning the topic:
Lindholm, P., and Saarma, M. (2010). Novel CDNF/MANF family of neurotrophic factors. Dev Neurobiol 70, 360-371.
Lindholm, P., Voutilainen, M.H., Lauren, J., Peranen, J., Leppanen, V.M., Andressoo, J.O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., et al. (2007). Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature 448, 73-77.
Lindahl, M., Danilova, T., Palm, E., Lindholm, P., Võikar, V., Hakonen, E., Ustinov, J., Andressoo, J.-O., Harvey, B. K., Otonkoski, T., Rossi, J. and Saarma, M. (2014). MANF is indispensable for the proliferation and survival of pancreatic -cells. Cell Rep. 7, 366-375.
Dear biochemistry students,
(in English below)
Älkää käyttäkö gmail-osoitteita yliopiston järjestelmissä, kuten WebOodissa. Tällä hetkellä Google ei vastaanota posteja oulu.fi -osoitteista (ainakaan kaikista), vaan lähettää ne bumerangina takaisin. Täten jos kurssin opettaja lähettää postia kurssilaisille (yksittäin tai joukkopostina WebOodin kautta), ne teistä, joilla on siellä gmail-osoite, jäätte ilman ko. postia. Samoin jos lähetätte gmailistanne postia opettajalle kysyäksenne jotain asiaa kurssia koskien, opettaja ei voi vastata viestiin.
Opettajilla ei ole velvollisuutta olettaa muuta kuin että opiskelijat käyttävät student.oulu.fi-osoitetta. Jos käytät muuta osoitetta, vastaat itse siitä, jos posti ei tule perille. Tietohallinto purkaa myös kaikki havaitut postin ohjaamiset oulu.fi-osoitteista muihin osoitteisiin (kuten gmail). Yliopisto on antanut jokaiselle opiskelijalle sähköpostiosoitteen virallisen (opiskeluun liittyvän) sähköpostin hoitamiseen - aivan kuten henkilökunnallekin - ja sitä edellytetään käytettävän!
Gmail currently returns mails from oulu.fi domain. This means that any student mail to/from gmail addresses are blocked. If you send mail to a teacher from a gmail address the teacher is not able to answer to it. SO YOU MUST USE YOUR xxxxxx(a)student.oulu.fi address in WebOodi and other university platforms and when communicating with staff members!!! University has given to every student and every staff member the oulu.fi address for professional mail and everyone is supposed to use that address. IT administration has also informed that all detected cases with automatic email forward from oulu.fi addresses to other addresses will be cut.
WBW,
Tuomo Glumoff
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Tuomo Glumoff, FT / PhD
yliopistonlehtori, dosentti / University lecturer, adjunct professor
Biokemian ja molekyylilääketieteen tiedekunta /
Faculty of Biochemistry and Molecular Medicine
Oulun yliopisto / University of Oulu
PL 5400 / PO Box 5400
90014 Oulun yliopisto
Finland
Käyntiosoite: Aapistie 7 A, 90220 Oulu
Sisäinen posti / internal mail: 5BMTK
Huone/office: F104A
Puh. 0294 481170 / Tel. +358 294 481170
email: tuomo.glumoff(a)oulu.fi
http://www.oulu.fi/fbmm/
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