Pro Gradu project: Interplay between hypoxia response and alcohol metabolism
We are looking for a highly motivated biochemistry or biology master's degree student for a project studying the molecular level determinants for an interplay between hypoxia-response and ethanol metabolism.
This in vitro cell-culture-based project is a part of a larger project, in which mice that have an activated hypoxia response (via genetic modification or pharmacological intervention) are fed ethanol to study whether they would be protected from alcohol-induced fatty liver. The goal of the in vitro cell experiments is to determine at the molecular level the mechanism behind the protective effect in vivo. During the project you will learn methods, such as in vivo mouse liver perfusion and primary hepatocyte isolation, cell culture methods, qPCR, Western blotting, immunofluorescence stainings and microscopy.
If you are interested please contact Prof. Peppi Karppinen to set up an interview, or myself for further details about the project. The project will start in the beginning of January 2016 or as soon as a suitable candidate has been found.
Best wishes,
Anna Laitakari, M.Sc., PhD Student
Biocenter Oulu Faculty of Biochemistry and Molecular Medicine University of Oulu, Finland