A PhD position in structural biology/biochemistry is available in my group. More information can be found at:
http://www.umu.se/english/about-umu/open-positions?languageId=1
search for "PhD-position in Chemistry (with focus on Biochemistry/Structural Biology)" Regards Elisabeth Sauer-Eriksson
Description This PhD position is part of a larger research project where we aim to design molecules - so-called inhibitors - that block bacterial virulence, i.e. the bacteria's ability to infect host cells. By not killing the bacteria, but rather blocking their virulence, the risk of developing resistance to the inhibitors is significantly reduced. Primarily, your studies will focus on identifying inhibitors that target the regulatory protein, PrfA, from the pathogen Listeria monocytogenes, but your studies will also include proteins from other pathogenic bacteria. The project group includes structural biologists, organic chemists and molecular biologists at Umeå University. The project can be described as a drug discovery project where your role is to determine and analyze structures of protein-molecule complex so that they can form the foundation for design of new and improved molecules. The structural studies will mainly be performed using X-ray crystallographic methods. Synthesis of new molecules and the effect of these on bacteria in vivo are made by our collaboration partners.
You can read more about the project in:
Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.https://www.ncbi.nlm.nih.gov/pubmed/26991105 Good JA, Andersson C, Hansen S, Wall J, Krishnan KS, Begum A, Grundström C, Niemiec MS, Vaitkevicius K, Chorell E, Wittung-Stafshede P, Sauer UH, Sauer-Eriksson AE, Almqvist F, Johansson J. Cell Chem Biol. 2016, 23(3):404-14.