Pro gradu thesis projects available in the field of cellular signaling at the Research Unit of Biomedicine in the group of Senior Research Fellow Ulla Petäjä-Repo (GPCRs team Oulu)
We investigate molecular mechanisms that regulate G protein-coupled receptor (GPCR) signaling. The available projects relate to the beta1-adrenergic receptor that regulates heart rate and contractility, as well as to the orphan GPR37, implicated in Parkinson's disease and glial cell differentiation. The projects aim to shed light on the functional significance of two post-translational processing events involving the N-terminal ectodomain of GPCRs: limited proteolysis and O-linked glycosylation. The work will involve multidisciplinary approaches using primarily cell culture-based assays. Depending on the project, the methods will include site-directed mutagenesis, plasmid preparation, cell culture and transfections, western blotting, confocal microscopy, radioligand binding and BRET (bioluminescent energy transfer) biosensor-based signaling assays. The work will also include data processing and analysis. Previous experience in these methods is desirable but not mandatory. We are looking for highly motivated science-driven students to join our team. The projects are available immediately but can also be started later in 2019. Introductory short-term practical training periods are also available. Enquiries are welcome at any time.
For more information, please contact Ulla Petäjä-Repo (ulla.petaja-repo@oulu.fimailto:ulla.petaja-repo@oulu.fi), Research Unit of Biomedicine, Faculty of Medicine, Aapistie 5B (Room F309) Tel. 040-7247328
================================================= Tuomo Glumoff, FT, Dosentti Koulutusdekaani & Yliopistonlehtori Dean for Education & Adjunct Professor
Biokemian ja molekyylilääketieteen tiedekunta / Faculty of Biochemistry and Molecular Medicine Oulun yliopisto / University of Oulu PL 5400 / PO Box 5400 90014 Oulun yliopisto Finland
Käyntiosoite: Aapistie 7 A, 90220 Oulu Sisäinen posti / internal mail: 5BMTK Huone/office: L219A Puh. 0294 481170 / Tel. +358 294 481170 email: tuomo.glumoff@oulu.fimailto:tuomo.glumoff@oulu.fi http://www.oulu.fi/fbmm/ =================================================