From: bco-bounces@lists.oulu.fi [mailto:bco-bounces@lists.oulu.fi] On Behalf Of Anita Tienhaara
Sent: 25. elokuuta 2009 12:38
To: FinBioNet@smtp-rs1.it.helsinki.fi
Subject: [Bco] Pre-Doctoral Fellowship in Molecular and Cellular Biology (Bordeaux, France)

Job Description:

An EU-FP7 Marie-Curie-supported pre-doctoral training fellowship is available for three years at an INSERM (Institut National de la Santé et de la recherche Médicale) laboratory. This project is a component of the Tissue Transmigration Training Network, T3Net. This Network aims to promote excellence in training in the fields of cell adhesion and cell migration, concentrating on the cellular structures mediating tissue invasion, known as podosomes and invadopodia.

Signaling and cellular features regulated by TGFbeta in arterial endothelial cells

Backgroud: TGFbeta plays an essential role in vascular homeostasis and alterations in TGFbeta biodisponibility is likely contribute to common (atherosclerosis) and rare (HHT, MFS, LDS) vascular diseases. We have discovered that TGFbeta causes formation of podosomes in endothelial cells. These are actin-based and integrin-enriched punctate adhesion microdomains localized at the plasma membrane. These structures recruit metalloproteases that are instrumental in the degradation of extracellular matrix. Our working hypothesis is that podosomes contribute to vessel repair.

Objectives: To find out under what conditions podosomes are formed in vitro, in vascular segments (ex-vivo) and in genetically engineered animals models (in vivo) and to study their role in vascular remodeling. These studies should provide important information about the role of TGFbeta in vascular physiology and pathology.

Profile: French scientist are not eligible for this fellowship unless they have been working in France for less than a year. Applicants should have an M.Sc. degree in molecular and cellular biology, biochemistry or related sciences. We seek an individual with a strong interest in advanced microscopic techniques as applied to biomedical research, and the ability to work in a research team and willing to move for extended intervals to our T3Net partner laboratories within Europe and possibly Canada (Toronto). A good command of the English language is mandatory.

Location: The laboratory is located at the European Institute of Chemistry and Biology near Bordeaux. This new institution provides an exceptional scientific environment, at the interface of different disciplines with first class scientific programs in physical-chemistry, chemistry and biology ( http://www.iecb.u-bordeaux.fr/ ,

Monthly salary 2100 € net + travel allowance

Deadline for application: September 30 th 2009, Starting date autumn 2009

Further enquiries and application

Contact Dr Elisabeth GENOT

Please send : (1) a curriculum vitae; (2) name and contact details of two potential referees (3) a cover letter outlining your background experience and zhy you are interested in this position: e.genot@iecb.u-bordeaux.fr

our website

http://www.iecb.u-bordeaux.fr/fileadmin/IECB/HTML/POLE4/GENOT/index.htm

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Anita Tienhaara

Institute of Biotechnology

P.O.Box 56 (Viikinkaari 9)

FIN-00014 University of Helsinki, Finland

tel +358-9-191 59656

fax +358-9-191 59550

email anita.tienhaara@helsinki.fi