Hei,
Gradupaikka tarjolla Prof. Johanna Myllyharjun ryhmässä Lääketieteellisen biokemian ja molekyylibiologian laitoksella.
There is a pro gradu project available in Prof. Johanna Myllyharju’s group at the Department of Medical Biochemistry and Molecular Biology. More info about the research in Myllyharju group can be found from Biocenter
Oulu web page http://www.oulu.fi/biocenter/groups/myllyharju
Hypoxia-inducible factor (HIF) prolyl-4-hydroxylases (HIF-P4Hs) isoenzymes are oxygen sensors that hydroxylate the HIF-α subunit under normoxia and are implicated in the mechanism of the organism
adaptation to low oxygen levels. Three HIF-P4H isoenzymes are known in mammals: HIF-P4Hs 1, 2, and 3. A fourth P4H (P4H-TM) that contains an endoplasmic reticulum transmembrane domain was recently identified by our group (Koivunen et al. 2007) and it is challenge
now to characterize it’s function. This pro gradu project will be about the roles of HIF-P4Hs in the brain, in particular in stroke disease. This project is heavily based on use of different transgenic mouse models. Methods will include primary cell culture
of different neural cell types isolated from mouse embryos, RNA extraction from cells and mouse tissue, quantitative PCR, Western blot, immunostaining, various functional assays on synaptic plasticity and cell death, etc.
For more information please contact,
Nadiya Byts
Looking forward,
Nadiya
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Nadiya Byts, Ph.D.
University of Oulu
Institute of Biomedicine
Department of Medical Biochemistry and Molecular Biology
P.O.Box 5000hj
FI-90014 University of Oulu
Finland