-----Original Message-----
From: bco-bounces@lists.oulu.fi [mailto:bco-bounces@lists.oulu.fi] On Behalf Of Anita Tienhaara
Sent: 1. joulukuuta 2008 10:28
To: FinBioNet@sender-03.it.helsinki.fi
Subject: [Bco] PhD Student position at Department of Biomedicine/Anatomy,Biocenter Kuopio

PhD Student position is available from January 2009 in Biocenter Kuopio, Department of Biomedicine/Anatomy. The project focuses on signals regulating hyaluronan synthesis, with potential applications in inflammation, diabetes and cancer.

The research group expands its findings (J Biol Chem.283: 7666, 2008) that glucose metabolites control the production of hyaluronan, an extracellular matrix polysaccharide with an important role in cancer (Semin Cancer Biol 18: 288, 2008) and inflammation. The project involves defining the signals that mediate the metabolic state of the cell to the transcriptional control of enzymes producing hyaluronan. Mass spectrometric analysis of O-GlcNAc- modification of cytosolic and nuclear proteins, phosphoprotein arrays, gene expression arrays, chromatin immunoprecipitation of transcription factors, plasmids for GFP-labeled proteins and their confocal tracking in live cells, and biochemical, histological and cell biological functional assays are part of the work. The hyaluronan research group

( http://www.uku.fi/biolaake/hyaluronaani.shtml ) currently constitutes of 2 professor level instructors, 2 postdocs, and 5 graduate students, and is affiliated to Biocenter Kuopio ( http://www.uku.fi/bck/members.shtml ) and the National Glycoscience Graduate School ( http://www.oppi.uku.fi/glyko/ ).

A person highly motivated in scientific research with a Master of Science degree is expected, and experience in one or more of the techniques listed above is desirable. Further information: Prof. Markku Tammi, Department of Biomedicine, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland,Â tel. +358-(0)40-7674826; email: tammi@uku.fi . Applications with CV, names of two referees, and a brief description of personal research interests are to be sent in the mail or email address above.

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Anita Tienhaara

Institute of Biotechnology

P.O.Box 56 (Viikinkaari 9)

FIN-00014 University of Helsinki, Finland

tel +358-9-191 59656

fax +358-9-191 59550

email anita.tienhaara@helsinki.fi