-----Original Message----- From: bco-bounces@lists.oulu.fi [mailto:bco-bounces@lists.oulu.fi] On Behalf Of Anita Tienhaara Sent: 20. helmikuuta 2013 14:31 To: finbionet Subject: [Bco] Graduate Student Positions at the Institute of Biotechnology, University of Helsinki
1-2 graduate student positions are available at the Institute of Biotechnology in the following projects/labs:
Stromal-epithelial interactions in tumour formation / Tomi P. M kel
The project leverages on our recent discoveries that stromal smooth muscle cells (Katajisto et al, Nat Genet 40, 455-, 2008) and fibroblasts (unpublished) have a critical role in development of gastrointestinal polyps following mutations of the LKB1 tumor suppressor kinas. The project will utilize new in vivo, organoid, and in vitro models to explore the underlying mechanisms including LKB1 substrate kinases and regulators of polarity, metabolism, and the tumor microenvironment. Previous experience in mouse models, signaling, cell/molecular biology, highcontent screening (HCS), or bioinformatics is advantageous.
Role of actin fibers in regulating E-cadherin based adhesions / Tea Vallenius
90% of cancer mortality results from the dissemination of cancer cells from primary tumours. To disseminate cancer cells have to acquire an efficient remodelling ability to migrate over tissue boundaries. The E-cadherin based adhesions together with the associated actin fibers at cell-cell junctions represent major remodelling sites. In some invading cancers E-cadherin is lost, but in others E-cadherin function perturbs through uncharacterized mechanisms, where actin fibers and their regulators have been often implicated. The project aims to identify molecular composition of actin fibers associated with E-cadherin and how these fibers remodel E-cadherin based adhesions. Previous experience in the actin research, advanced cell/molecular biology and mouse models is advantageous.
The projects are integrated to a national project translating new knowledge on the tumour microenvironment to new combinatorial therapies with over a hundred scientists working toward a common goal. As a graduate student at the Institute of Biotechnology you will also have an opportunity for developing transferable skills within a highly dynamic international environment.
Successful candidates will have a strong interest in cancer biology, demonstrated ability to carry out outstanding research, and interest to join an ambitious international team. The salary is 2100-2600 /month.
Applications are to be sent between February 20 - March 20, 2013 by e-mail (Subject: PhDstudent2013) to Tea Vallenius (tea.vallenius(at)helsinki.fi) as a single PDF document including a short description of suitability (max. 1 pages), CV (max 2 pages), and preferably names and contact information of 2 references. Please do not hesitate to contact us with any questions; positions may be filled prior to deadline.
Tomi M kel +358-50-5286128, bi-director(at)helsinki.fi http://www.biocenter.helsinki.fi/bi/makela/
Tea Vallenius +358-9-19159616, tea.vallenius(at)helsinki.fi http://www.biocenter.helsinki.fi/bi/vallenius/
-- -- Communications Officer Institute of Biotechnology P.O. Box 56 FI-00014 University of Helsinki FINLAND phone +358 9 191 59656 mobile +358 50 318 5065 fax +358 9 191 59550
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