-----Original Message----- From: bco-bounces@lists.oulu.fi [mailto:bco-bounces@lists.oulu.fi] On Behalf Of Anita Tienhaara Sent: 11. huhtikuuta 2011 8:45 To: finbionet Subject: [Bco] Postdoctoral fellow/PhD position in cancer biology, University of Turku

Postdoctoral fellow/PhD position in cancer biology

A post-doctoral fellow/PhD position is available in the laboratory of Jukka Westermarck at the Centre for Biotechnology (CBT), University of Turku, Turku, Finland (http://www.btk.fi/research/research-groups/westermarck/). CIP2A is a novel clinically relevant human oncoprotein recently identified by our laboratory (Junttila, et al., Cell, 130, 2007). Current results clearly indicate that CIP2A might be a potential target protein for future cancer therapies. At the molecular level CIP2A functions as an inhibitor of an essential protein phosphatase complex PP2A, but the molecular mechanisms regulating CIP2A interaction with PP2A or PP2A complex assembly in cancer cells are very poorly understood.

The aim of the project is to develop novel fluorescent reporters for studying PP2A complex assembly and CIP2A function. The future prospect of the work is to use these reporters for high-throughput screening of small molecule compounds regulating PP2A and CIP2A functions. The work will be done in collaboration with Dr. Daniel Abankwa�s laboratory (CBT, Turku), who is using cutting-edge cellular imaging (Fluorescence Lifetime Imaging Microscopy, FLIM, and STED-nanoscopy), high-throughput methodological approaches (high-content and cytometer chemical- and RNAi-screening) to study cancer signaling. Position is available immediately and candidates will be considered until the positions are filled. Position is initially for two years with a possibility to extension depending on the progress of the project.

Centre for Biotechology, University of Turku is a top-quality research center harbouring excellent core facilities for bioimaging, proteomics, genomics and crystallography. At the center works several research groups with distinguished publication profile in world leading journals (http://www.btk.fi/home/main/). Turku is a beautiful old city located in South-Western corner of Finland surrounded by a magnificient archipelago with thousands of small islands (http://www.saaristo.org/eng/).

We are looking for hard-working and ambitious candidates with proven track record of successful scientific work. Solid previous experience on bioimaging and use of advanced microscopy techniques will be a clear asset. To apply, send to dabankwa@abo.fi, preferably as one merged pdf: your CV and an application letter clearly describing your previous achievements in the field and especially your experience on use of advanced microscopy techniques. Also include names and contact information of three references.

Recent publications:

Junttila et al.,: Cell, 130, 51�62, 2007. Wu et al.,: Nature Methods, 6, 75-77, 2009 Khanna et al.,: Journal of the National Cancer Institute, 101, 793-805, 2009. Abankwa et al.,: Embo J., 27, 727-735, 2008 Abankwa et al.,: PNAS, 107, 1130-1135, 2010.

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