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The Problem
Thorough extracellular vesicle (EV) characterization is a tall order, even with highly purified cell culture samples. Adding in lipoproteins, cellular debris, and protein aggregates only obscures results, making it even
more difficult to confidently identify real EVs in a sea of similarly-sized particles. When working with complex biofluids, limited sample volumes, or rare EV subpopulations, the challenge only increases.
The Solution
Leprechaun simplifies EV analysis by immuno-capturing vesicles on its Luni consumable before measuring particle size and concentration, while simultaneously profiling EV phenotype across up to four surface or cargo markers
— all from less than 25 µL of sample. Compatible with a wide range of sample types, from cell culture media to crude plasma, Leprechaun eliminates the need for upfront purification. With sensitivity down to 5E5 particles/mL, true single-particle analysis,
and sizing down to 35 nm, Leprechaun inspires confident EV characterization, even for the smallest and rarest populations.
The Proof
In this webinar, you’ll discover how Leprechaun brings together single-particle interferometry with immunofluorescence to deliver a complete picture of EV samples. Learn how to get a simple titer of EVs in your sample,
assess EV cargo loading efficiency, and obtain a detailed breakdown of all EV subpopulations in your sample.
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