Crc May 2019

crc@lists.oulu.fi

11 participants
41 discussions

Kontinkangas Campus Seminar Series on Wed May 15 - Speaker Dr. Alberto Podjarny: The use of neutron crystallography to solve biological puzzles
by Mirja Peltola 10 May '19

10 May '19

Kontinkangas Campus Seminar Series<https://www.oulu.fi/uniogs/dp/hbsdp/guest-seminars> Dear all, Next week on Wed 15thof May 15:00-16:00 in auditorium F101 Dr. Alberto Podjarny from University of Strasbourg, France, will give a lecture with a title: The use of neutron crystallography to solve biological puzzles Short introduction (http://www.igbmc.fr/research/department/3/team/113/): "Our team aims to study in fine detail the structural basis of ligand binding to macromolecules involved in important diseases (targets) and the corresponding structure activity relationships (SAR), in order to gather information for the "hit to lead" discovery process. We determine the crystallographic structures of proteins and macromolecular complexes, in the presence and in the absence of natural or synthetic ligands. We develop new methodologies, in particular for high resolution X-Ray and neutron diffraction, to improve the quality of the structures of ligand-target complexes. We collaborate with several national and international groups for the production of ligands and for the modeling of ligand binding, which we use to complement the experimental structural information. In summary we apply an integrated approach to Experimental Structure Based Drug Design. In structural biology our expertise covers cloning, protein expression in prokaryotic and eukaryotic cells, large scale protein production, purification, protein crystallization and protein crystallography. The latter is the main tool to visualize macromolecular complexes. We develop special crystallographic methods based both on high resolution X-Rays (PX) and on Neutrons (NPX) diffraction, leading to very accurate models including the observation of protonation states and hydration. This exceptional level of joint information is then used to explain very precisely the mechanisms of action and inhibition. We also study in detail the thermodynamics of binding. In this sense we apply several biochemical and biophysical techniques, including Isothermal Titration Calorimetry (ITC), Mass Spectrometry (MS), Surface Plasmon Resonance (SPR) and analytical ultra-centrifugation. As a significant example, we have studied one protein, human Aldose Reductase, at the highest resolution ever obtained so far with X-Ray Crystallography (0.66 Å) for a medium size enzyme (36 kDa). We have used this information for the development of pharmaceutical leads. One of these leads (Fidarestat) is currently in phase III of clinical trials." Coffee and pulla service before the seminar! PhD Students' credits: Attendance to 10 seminars -> 0,5 ECTS Best wishes, Mirja ------------------------------------------------------------------------------------------------------ Mirja Peltola Koordinaattori | Coordinator Oulun yliopisto | University of Oulu Terveys- ja biotieteiden tohtoriohjelma | Health and Biosciences Doctoral Programme Tel. 0294 48 5447 PO Box 5000, FI-90014 OULUN YLIOPISTO (Aapistie 5A, Room 474B) www.oulu.fi<http://www.oulu.fi/yliopisto> [cid:image002.jpg@01D50722.3A298620]

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FW: Updated funding opportunities list
by Antti Haapalainen 10 May '19

10 May '19

From: Jaana Liimatainen <jaana.liimatainen(a)oulu.fi> Sent: 10. toukokuutata 2019 8:25 To: Jaana Liimatainen <jaana.liimatainen(a)oulu.fi>; LTK <ltk-staff(a)oulu.fi>; mrcouluohjaajat(a)lists.oulu.fi; fbmm(a)lists.oulu.fi; 'bco(a)lists.oulu.fi' (bco(a)lists.oulu.fi) (bco(a)lists.oulu.fi) <bco(a)lists.oulu.fi>; hbsdp(a)lists.oulu.fi Cc: Emma Pirilä <emma.pirila(a)oulu.fi> Subject: RE: Updated funding opportunities list Dear researchers, I have updated the Funding opportunities list today and it can be found in - OneDrive (Klick<https://unioulu-my.sharepoint.com/:x:/g/personal/jliimata_univ_yo_oulu_fi/E…>). This is the easiest option. The list is read-only, but can be downloaded into Excel. - Eduuni of FMed<https://tt.eduuni.fi/sites/ou-fmed/_layouts/15/WopiFrame.aspx?sourcedoc=/si…> - Eduuni of FBMM<https://tt.eduuni.fi/sites/ou-bmtk/_layouts/15/WopiFrame.aspx?sourcedoc=%7b…> You can access Eduuni through Notio. If you are new to Eduuni you need to register with your university's email address (more info: https://notio.oulu.fi/en/guides/Pages/Eduuni-palvelut.aspx). If you do not have a university email address and thus no access to Eduuni and to the list, and the OneDrive version does not work, please send me or Emma, emma.pirila(a)oulu.fi<mailto:emma.pirila@oulu.fi> an e-mail and we 'll send the file. Cheers, Jaana Jaana O. Liimatainen, PhD Coordinator Faculty of Medicine Aapistie 5A FIN-90230 University of Oulu tel. +358 294 487 459 mobile +358 50 590 4561 Jaana.Liimatainen[at]oulu.fi

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CRC:n taukohuoneen roskien lajittelu / garbage sorting in CRC coffee room
by Antti Haapalainen 10 May '19

10 May '19

Hei, Pyynnöstä pyytäisin kaikkia kiinnittämään huomiota roskien lajitteluun CRC:n taukohuoneessa. Taukohuoneessa on erilliset keräysastiat metalli-, lasi-, pahvi-, bio- ja sekajätteelle. Erityisesti lasiroska-astiaan kerääntyy muutakin kuin lasiroskaa. Hi, On request, I would ask everyone to pay attention to the sorting of garbage in the CRC coffee room. There are separate trash bins for metal, glass, cardboard, bio and mixed waste. Especially the trash bin meant only for glass waste quite often contains other waste, as well. Terv. Antti

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MRC Oulu News - May 10 - Public defences of dissertations
by Katja Riipinen 09 May '19

09 May '19

MRC Oulu News Hello everyone, Tomorrow, Friday May 10, there will be the following public defences of dissertations: Genetic aetiologies and phenotypic variations of childhood-onset epileptic encephalopathies and movement disorders<https://www.oulu.fi/yliopisto/node/58981> Doctoral candidate: Licentiate of Medicine Jonna Komulainen-Ebrahim Date: 10 May 2019, starting at 12.00 Location: Auditorium 12, Department of Pediatrics, Oulu University Hospital (Kajaanintie 50) Opponent: Docent Tarja Linnankivi, Helsinki University Hospital Custos: Professor Johanna Uusimaa, University of Oulu More about the thesis: http://jultika.oulu.fi/Record/isbn978-952-62-2235-6 Rehabilitation after hip fracture − comparison of physical, geriatric and conventional treatment<https://www.oulu.fi/yliopisto/node/58815> Doctoral candidate: Licentiate of Medicine Antti Lahtinen Date: 10 May 2019, starting at 12.00 Location: Auditorium 1, Oulu University Hospital (Kajaanintie 50) Opponent: Professor Ilkka Kiviranta, University of Helsinki Custos: Professor emeritus Pekka Jalovaara, University of Oulu More about the thesis: http://jultika.oulu.fi/Record/isbn978-952-62-2215-8 Please feel free to distribute this announcement to others who might be interested. Best regards, Katja ---------------------------------------------------------------- Katja Riipinen Koordinaattori | Coordinator Medical Research Center Oulu<https://www.oulu.fi/mrc/> | MRC Oulu Tel. 0294 48 5909, Mobile +358 50 472 9414 PO Box 5000, FI-90014 OULUN YLIOPISTO (Aapistie 5A, Room 347B) www.oulu.fi<http://www.oulu.fi/yliopisto> [cid:image001.jpg@01D50641.1EA8FD90][cid:image002.png@01D50641.1EA8FD90]

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MUISTUTUS: professoriluennot 9. toukokuuta / professor lectures on May 9
by Anne Vainionpää 08 May '19

08 May '19

Hei, Kontinkankaan kampuksen professoriluentotilaisuus pidetään torstaina, 9. toukokuuta klo 13.00 alkaen Leena Palotie -salissa. Tilaisuus on LTK:n ja BMTK:n yhteinen, ja kuulemme Lääketieteellisen tiedekunnan edustajana Nina Hautalan esityksen, sekä Biokemian ja molekyylilääketieteen tiedekunnan edustajina Gonghong Wein ja Lauri Eklundin esitykset. Kontinkangas campus professor inauguration lecture event will be arranged on Thursday, May 9 at 13.00 in the Leena Palotie -lecture hall. We shall hear professors from both faculties, FMed and FBMM, Nina Hautala representing the Faculty of Medicine, Gonghong Wei and Lauri Eklund representing the Faculty of Biochemistry and Molecular Medicine. Luentojen aiheet / Title of talks: Professori Nina Hautala: Diabetes ja silmä - valoa näkyvissä Professor Gonghong Wei: Translating (prostate) cancer genomic discoveries to the clinic Professori Lauri Eklund: Verisuoniston muodostumisen molekulaariset säätelijät Tervetuloa mukaan professoriluentotilaisuuteen! / Welcome to join in the event! Tervehtien / Best wishes, Anne Vainionpää Johdon assistentti / Management assistant LTK / FMed

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FW: The Olav Thon Foundation 2020 - support for Nordic research projects in medicine 2020
by Antti Haapalainen 08 May '19

08 May '19

From: Jaana Liimatainen <jaana.liimatainen(a)oulu.fi> Sent: 8. toukokuuta 2019 11:04 To: LTK <ltk-staff(a)oulu.fi>; fbmm(a)lists.oulu.fi; hbsdp(a)lists.oulu.fi Subject: The Olav Thon Foundation 2020 - support for Nordic research projects in medicine 2020 Dear researcher please note The Olav Thon Foundation Announcement - Support for Nordic research projects in medicine 2020. More info see email below and attachment. Cheers Jaana From: Gry Kolbjørnsen <gry.kolbjornsen(a)admin.uio.no<mailto:gry.kolbjornsen@admin.uio.no>> Sent: tiistai 7. toukokuuta 2019 15.09 To: Gry Kolbjørnsen <gry.kolbjornsen(a)admin.uio.no<mailto:gry.kolbjornsen@admin.uio.no>> Subject: The Olav Thon Foundation 2020 - support for Nordic research projects in medicine 2020 To Universities and academic institutions in the Nordic countries The Olav Thon Foundation Announcement - Support for Nordic research projects in medicine 2020 We kindly ask you to forward the announcement to relevant people in your organization. Please, see the attached announcement for further details and contact information. Deadline for submission is 15 September 2019. Sincerely, on behalf of the Olav Thon Foundation Gry Kolbjørnsen<https://www.uio.no/english/people/los/aks/ses/grykolbj/index.html> Advisor, Department of Communications and External Relations, The University of Oslo +47 91575622 [cid:image001.gif@01D500B8.A3BE0720]

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Soluviljelyn satulatuolit ja CRC:n ylimääräiset tuolit
by Antti Haapalainen 07 May '19

07 May '19

Hei, Soluviljelyyn tilatut 4 kpl satulatuoleja saapuivat, 2 satulatuolia per soluviljelyhuone (341B, 342B). Alustavan suunnitelman mukaan sovittiin, että ko soluviljelyhuoneisiin tulisi 2 kpl satulatuoleja ja 1 kpl "normaalituoli". Jos haluatte mikroskooppia varten myös tuolin, jättäkää siinä tapauksessa vielä yksi "normaalituoli" soluviljelyhuoneeseen. Viekää loput tuolit soluviljelytiloista pois. Viekää ylimääräiset penkit CRC:n soluviljelytilojen ikkunoiden edustalle (CRC:n pääsisäänkäynnin vieressä) viimeistään torstaina. HUOM!!! Jos CRC:n muissa tiloissa on ylimääräisiä penkkejä (haittana), viekää nämäkin penkit CRC:n soluviljelytilojen ikkunoiden edustalle (CRC:n pääsisäänkäynnin vieressä) viimeistään torstaina. Pyydän hakemaan ylimääräiset penkit pois perjantaina 10.5. Terv. Antti

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Väitös perjantaina 10.5.
by Salla Kangas 07 May '19

07 May '19

Hei CRC:n väki, Tiedoksenne, että Jonna Komulainen-Ebrahim lastenneurologian tutkimusryhmästä väittelee perjantaina klo 12 OYSin Lastenklinikan luentosalissa 12. Linkki tiedotteeseen: https://www.oulu.fi/yliopisto/node/58981 T. Salla Salla Kangas, Postdoctoral researcher PEDEGO research unit/Pediatric Neurology division Faculty of Medicine, University of Oulu, Finland -------------------------------------------- P.O. Box 5000 (Aapistie 5A) FIN-90014 University of Oulu, Finland -------------------------------------------- Office 352B/Kieppi building tel. +358 50 342 4756 (office) e-mail: salla.kangas(a)oulu.fi<mailto:salla.kangas@oulu.fi>

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FW: Kontinkangas research seminars in May and June
by Antti Haapalainen 07 May '19

07 May '19

From: Pirkko Huhtala <pirkko.huhtala(a)oulu.fi> Sent: 7. toukokuuta 2019 10:06 To: bco(a)lists.oulu.fi; fbmm(a)lists.oulu.fi; mrcouluohjaajat(a)lists.oulu.fi; ltk-all <ltk-all(a)oulu.fi> Subject: Kontinkangas research seminars in May and June Dear all, we have the following Kontinkangas seminars for May and June. The seminars are open for all, welcome! Time for networking and coffee 15 min before the seminars. May 16 (Thursday) Johanna Magga, FMED, BCO emerging NOTE morning seminar! 8:45-9:15 Ravintolaraitti (coffee at 8.30) Meeting with the TGF* family: Growth differentiation factors in cardiovascular diseases May 23 (Thursday) Two presentations: Justus Reunanen, BCO, FMED and Terhi Tapiainen, FMED, OUH, BCO emerging F202, 15.00-16 Extracellular vesicles of the human gut microbiota Fetal microbiome and health May 28 (Tuesday) Niels Behrendt, Biotech Research and Innovation Center, University of Copenhagen F202, 15.00-16 The endocytic collagen receptor uPARAP/Endo180: Physiological and pathological roles and potential as a tumor target May 31 (Friday) Ad-hoc seminar by Scott F. Gilbert, Development biologist, emeritus F202, 13:00-14 Holobiont evo-devo: the importance of developmental symbiosis for evolution June 6 (Thursday) Gonghong Wei, BCO and FBMM F202, 15:00-16 Translating prostate cancer genetic discoveries to the clinic Pirkko Huhtala, Ph.D. Coordinator Biocenter Oulu University of Oulu Mailing address: P.O.Box 5000, FIN-90014 University of Oulu Finland Street address: 476B, Aapistie 5A, FIN-90220 Oulu Tel. sis/int. 486101, ulk./Ext. 0294 486101 Tel. +358-294 486101 e-mail pirkko.huhtala(a)oulu.fi<mailto:pirkko.huhtala@oulu.fi> www.oulu.fi/biocenter<http://www.oulu.fi/biocenter>

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Orionin Tutkimussäätiön apurahat/Orion research foundation grants
by Emma Pirilä 06 May '19

06 May '19

Dear researchers, please find attached (in Finnish) information about the Orion Research Foundation call for applications and from this link (in English): https://www.orion.fi/en/rd/orion-research-foundation/orion-research-foundat… Best regards, Emma ************************ Emma Pirilä, PhD Research Funding Specialist Faculty of Medicine Faculty of Biochemistry and Molecular Medicine Biocenter Oulu Aapistie 5A, 2nd floor FIN- 90230 University of Oulu Finland Phone: +358503426428 e-mail: emma.pirila(a)oulu.fi<mailto:emma.pirila@oulu.fi> ************************

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Crc May 2019