From: bco-bounces@lists.oulu.fi [mailto:bco-bounces@lists.oulu.fi] On Behalf Of anita.tienhaara@helsinki.fi Sent: 1. marraskuuta 2010 9:30 To: FinBioNet Subject: [Bco] PhD student position in structure-function studies of small GTPases in cancer

PhD student position in structure-function studies of small GTPases in cancer in the Mechanism and Biosensors of small GTPases Group of Daniel Abankwa at the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku Finland ( http://www.btk.fi www.btk.fi ).

Turku is a beautiful old city located in South-Western corner of Finland surrounded by a magnificent archipelago with thousands of small islands ( http://www.saaristo.org/eng/ http://www.saaristo.org/eng/ .

Our research focuses on the membrane organization and signaling activity of small GTPases of the Ras-, Rho- and Rab-family. We have recently described a novel membrane-orientation switch III region for Ras proteins, which profoundly influences their biology (Abankwa D et al. (2008) Embo J 27(5): 727-735; Abankwa D et al. (2010) PNAS 107 (3): 1130-1135). We will be using cutting-edge cellular imaging (Fluorescence Lifetime Imaging Microscopy, FLIM, and STED-nanoscopy), high-throughput methodological

approaches (high-content and cytometer chemical- and RNAi-screening) and animal models to answer exciting questions around this newly discovered mechanism.

The Centre for Biotechnology offers state-of-the-art research facilities for bioimaging, proteomics, genomics, crystallography, which support excellence in research in the greater Turku area. The Cell Imaging Core features very good equipment for life-cell imaging, high-content and confocal microscopy, as well as state of the art FACS service and highthroughput

flow cytometry. In particular, it serves as the Nordic reference site for the Leica STimulated Emission Depletion (STED)-superresolution microscope.

We are looking for candidates with exceptional motivation, who recently earned their masters degree in a discipline related to life sciences or biophysics and experience and/or interest with protein purification, fluorescence imaging, flow cytometry and/or animal cancer models. Experience in molecular biology techniques is indispensable. The stipend 1400 €/month net (not taxable) is commensurate with typical university salary scales for graduate students.

Please send preferably as one merged pdf: a short CV that highlights your most outstanding achievements, as well as the email contacts of 2-3 referees (these may also be course advisors) and a brief description that highlights your most outstanding achievements and your specific motivation to join the group (approx. 1/2 A4 page) to daniel.abankwa-at-btk.fi with the subject line "research candidate". The positions commence at the beginning of 2011. Applications are open from 1. November 2010 until the positions are filled.

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Anita Tienhaara

Institute of Biotechnology

P.O. Box 56

FIN-00014 University of Helsinki, finland

tel. +358 9 191 59656

fax +358 9 191 59550

anita.tienhaara@helsinki.fi